MacRae F Linton Selected Research

4-oxo-2-nonenal

12/2019

Modified sites and functional consequences of 4-oxo-2-nonenal adducts in HDL that are elevated in familial hypercholesterolemia.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

MacRae F Linton Research Topics

Disease

66	Atherosclerosis 01/2022 - 06/2001
23	Inflammation (Inflammations) 01/2021 - 04/2002
11	Insulin Resistance 01/2022 - 06/2001
9	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 01/2021 - 07/2003
8	Dyslipidemias (Dyslipidemia) 01/2019 - 07/2003
7	Cardiovascular Diseases (Cardiovascular Disease) 07/2021 - 07/2003
7	Atherosclerotic Plaque (Atheroma) 01/2019 - 01/2005
7	Metabolic Syndrome (Dysmetabolic Syndrome X) 02/2012 - 10/2002
6	Obesity 01/2021 - 12/2003
6	Body Weight (Weight, Body) 01/2019 - 11/2004
6	Hypercholesterolemia 12/2011 - 10/2002
5	Coronary Disease (Coronary Heart Disease) 01/2019 - 01/2001
4	Necrosis 01/2019 - 12/2011
4	Coronary Artery Disease (Coronary Atherosclerosis) 01/2019 - 06/2005
4	Thrombosis (Thrombus) 02/2012 - 10/2002
3	Type 2 Diabetes Mellitus (MODY) 01/2021 - 06/2007
3	Myocardial Infarction 10/2019 - 01/2006
3	Infections 01/2019 - 02/2011
3	Hypertriglyceridemia 07/2017 - 07/2014
2	Chronic Renal Insufficiency 07/2021 - 02/2015
2	Kidney Diseases (Kidney Disease) 07/2021 - 01/2021
2	Genetic Risk Score 01/2021 - 01/2019
2	Fatty Liver 01/2021 - 01/2018
2	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 11/2010
2	Stroke (Strokes) 10/2019 - 07/2003
2	Hypertension (High Blood Pressure) 12/2018 - 07/2003
2	Rheumatoid Arthritis 12/2016 - 01/2016
2	Chronic Kidney Failure (Chronic Renal Failure) 02/2015 - 01/2011
2	Abdominal Aortic Aneurysm 01/2012 - 06/2011
2	Hyperlipidemias (Hyperlipidemia) 03/2004 - 10/2002
1	Metabolic Diseases (Metabolic Disease) 01/2022

Drug/Important Bio-Agent (IBA)

25	Apolipoproteins E (ApoE)IBA 01/2019 - 06/2001
22	CholesterolIBA 07/2021 - 12/2002
21	LipidsIBA 01/2022 - 06/2001
17	LDL Receptors (LDL Receptor)IBA 01/2019 - 04/2002
15	Proteins (Proteins, Gene)FDA Link 07/2021 - 12/2003
14	ApolipoproteinsIBA 12/2014 - 06/2001
12	Lipoproteins (Lipoprotein)IBA 01/2022 - 12/2003
12	oxidized low density lipoproteinIBA 10/2019 - 07/2003
10	HDL LipoproteinsIBA 07/2021 - 12/2003
9	LDL Lipoproteins (beta Lipoproteins)IBA 01/2021 - 11/2002
7	HDL CholesterolIBA 07/2021 - 12/2011
7	LDL CholesterolIBA 01/2021 - 07/2003
7	Triglycerides (Triacylglycerol)IBA 01/2021 - 03/2004
7	Fatty Acid-Binding ProteinsIBA 06/2011 - 06/2001
6	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2021 - 01/2001
6	Scavenger Receptors (Scavenger Receptor)IBA 01/2017 - 06/2005
5	isolevuglandinIBA 07/2021 - 06/2015
5	Apolipoprotein A-I (Apolipoprotein A1)IBA 07/2021 - 10/2003
5	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 10/2002
5	Protein Isoforms (Isoforms)IBA 06/2019 - 11/2014
4	Insulin (Novolin)FDA Link 01/2021 - 10/2002
4	Low Density Lipoprotein Receptor-Related Protein-1 (LDL-Receptor Related Protein)IBA 01/2019 - 03/2007
4	C-Reactive ProteinIBA 12/2018 - 07/2003
4	Biomarkers (Surrogate Marker)IBA 01/2017 - 11/2007
4	AngiotensinsIBA 06/2011 - 08/2007
3	RNA (Ribonucleic Acid)IBA 07/2021 - 12/2002
3	Fatty Acids (Saturated Fatty Acids)IBA 01/2021 - 04/2002
3	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 11/2017 - 10/2007
3	CollagenIBA 01/2017 - 08/2007
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2016 - 03/2007
3	Proprotein Convertase 9IBA 01/2016 - 12/2011
3	Pharmaceutical PreparationsIBA 01/2016 - 03/2004
3	Type 1 Angiotensin ReceptorIBA 12/2011 - 12/2002
3	Angiotensin IIIBA 12/2011 - 11/2004
3	Adenosine Triphosphate (ATP)IBA 02/2009 - 12/2002
3	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 04/2004 - 10/2002
3	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 04/2004 - 04/2002
2	EnzymesIBA 01/2021 - 12/2003
2	MicroRNAs (MicroRNA)IBA 01/2021 - 01/2019
2	AutoantibodiesIBA 05/2020 - 01/2017
2	Mechanistic Target of Rapamycin Complex 2IBA 06/2019 - 01/2018
2	CC ChemokinesIBA 01/2019 - 10/2018
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2019 - 01/2019
2	Fibric Acids (Fibrates)IBA 11/2017 - 03/2004
2	F2-Isoprostanes (F2 Isoprostanes)IBA 12/2016 - 11/2007
2	Adalimumab (Humira)FDA Link 01/2016 - 01/2016
2	CytokinesIBA 02/2015 - 11/2010
2	Apolipoproteins B (ApoB)IBA 07/2014 - 10/2007
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 06/2011 - 03/2004
2	Interleukin-6 (Interleukin 6)IBA 01/2011 - 04/2010
2	Vitamin E FDA LinkGeneric 09/2010 - 11/2007
2	Peptide Hydrolases (Proteases)FDA Link 06/2008 - 08/2007
2	Messenger RNA (mRNA)IBA 08/2007 - 12/2002
2	ElastinIBA 08/2007 - 11/2004
2	EicosanoidsIBA 04/2004 - 10/2002
2	ATP-Binding Cassette Transporters (ABC Transporters)IBA 10/2003 - 12/2002
2	Indomethacin (Indometacin)FDA LinkGeneric 10/2002 - 04/2002
2	rofecoxib (Vioxx)FDA Link 10/2002 - 04/2002
1	CarbohydratesIBA 01/2022
1	Transfer RNA (tRNA)IBA 01/2022
1	osteoblast cadherinIBA 10/2021
1	Malondialdehyde (Propanedial)IBA 07/2021
1	AntioxidantsIBA 07/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021

Therapy/Procedure

14	Therapeutics 01/2022 - 01/2001
3	Bone Marrow Transplantation (Transplantation, Bone Marrow) 08/2015 - 06/2001
3	Cell Transplantation 01/2011 - 10/2002
2	Drug Therapy (Chemotherapy) 01/2019 - 01/2016
2	Transplantation 03/2007 - 11/2003